Most not too long ago, it has been identified that conolidine and the above mentioned derivatives act about the atypical chemokine receptor three (ACKR3. Expressed in related areas as classical opioid receptors, it binds to the wide array of endogenous opioids. As opposed to most opioid receptor
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Gene expression Assessment uncovered that ACKR3 is very expressed in various brain locations similar to significant opioid action centers
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